Immunology Laboratory creates "humanized mice" which harbor human cells and tissues through the development of immunodeficient mice. Severe immunodeficient “NOG” mice developed by CIEM are suitable for reconstituting the human hematopoietic and immune systems. Those “humanized mice” provide unique opportunities to examine various functions or characteristics of human cells in vivo. Immunology laboratory has been developing “more advanced humanized mice” through genetic modifications, which are superior to the parental NOG mice in terms of human hematopoiesis and immune functions. These mice are useful for drug discovery and safety studies.
Immunology Laboratory
Human Disease Model Laboratory is developing novel humanized model animals and investigating the pathological mechanisms of immunological and hematological diseases by using these models. Our aim is to apply the humanized model animals for drug discovery research in preclinically and to develop the therapeutics. We also actively collaborate with the researchers in academic institutes, pharmaceutical companies, and etc. to facilitate their basic and translational researches.
Human Disease Model Laboratory
Liver Engineering Laboratory focuses on the development of liver-humanized mice as an animal experiment model that can be used for research on infectious diseases such as hepatitis virus and malaria and development of new drugs. More than 80% of the liver of a liver-humanized mouse is consisted of human hepatocytes, and it has been revealed that not only expression patterns of drug metabolism related genes and plasma proteins, but also properties of drug metabolism are similar to those in humans.
Liver Engineering Laboratory
Mice and humans are physiologically and anatomically very different, and cognitive functions such as perception, memory, learning, thinking, and decision are especially different between human and mice. Therefore, non-human primate models that have many physiological features to similar to those in humans are important. We aim to develop a reliable delivery system and safe new drugs and novel therapeutics for patients through developmental engineering and reproductive physiology of the common marmoset, a small primate species.
Applied Developmental Biology Laboratory
Animal models of human diseases play a significant role in elucidation of disease mechanisms and the assessment of new drugs and novel therapeutics. The common marmoset, a nonhuman primate species, bridges a gap between humans and rodent laboratory animals. We advance research for the development of disease models and veterinary care for applying common marmosets as human disease models.
Disease Model Animal Laboratory
Reproductive Engineering Laboratory is investigating methods for collection, cryopreservation, and individual restoration of germ cells such as oocytes, sperms, and embryos, the origin of biological phenomena. These researches are applied in genome editing and the creation of genetically modified animals.
Reproductive Engineering Laboratory
In in vivo experimental medicine, the ultimate goals of life science are the elucidation of biological functions of humans and triumph over disease. For these goals, we have been developing fundamental technologies over many years. Imaging Analysis Laboratory performs in vivo imaging using magnetic resonance imaging (MRI), micro X-ray CT, and in vivo fluorescence imaging.
Imaging Analysis Laboratory
The Metabolic Systems Laboratory studies the crosstalk between metabolism and epigenetics and how alterations in the cellular system are crucial to enable mammalian development and germ cell differentiation, including eggs and sperm, or contribute to etiologies such as cancer, developmental defects, or infertility.Our laboratory is also interested in application of “imaging metabolomics (IM)” to understanding pathogenesis of human cancer and neurodegenerative diseases. IM includes imaging mass spectrometry, surface-enhanced Raman spectrometry (SERS), and ultra- high field functional magnetic resonance imaging (fMRI). In November 2023, CIEM introduced 11.7T fMRI.
Metabolic Systems LaboratoryiMScope (Imaging mass spectroscopy)
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