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代表的な実験動物

NOGマウス｜ヒト化マウス

NOG mouse
正式名 NOD.Cg-PrkdcscidIl2rgtm1Sug/ShiJic
簡略名 NOD/Shi-scid,IL-2RγKO
日本特許 第3,753,321号
米国特許 No.7,145,055
欧州特許 No.1,338,198
日本商標登録 第4,823,423号
米国商標登録 No.3,118,040
EU商標登録 No.3,736,758

NOG マウスの開発

ヒト細胞、ヒト組織をIn vivoで解析できるヒト化マウスは、創薬のための研究材料としての利用のみならず、新薬の前臨床試験やヒト細胞の分化、機能解析等の基礎研究にも有用であり、医療への貢献が充分期待できる実験動物です。

1988年ヒト化マウスのさきがけとして、免疫不全SCIDマウス（Bosma CG et al., Nature 1983）にヒト造血系組織（McCune JM et al., Science 1988）、もしくはヒト末梢リンパ球（Mosier DE, et al., Nature 1988）を移植したいわゆるSCID-huマウスが開発されました。その後、SCIDマウスを改良したNOD/scidマウスの開発によって、SCID マウスを上回るヒト細胞の生着が可能となりましたが、in vivo解析モデルとしては不十分な点が多く残されておりました。

当研究所では、NOD/scidマウスと数種のサイトカインレセプター共通ドメインである IL-2レセプターγ鎖ノックアウト (IL2RγKO) マウス（Ohbo K et al., Blood 1996）を組み合わせることにより、極めて重度な複合型免疫不全を呈する“NOG (NOD/Shi-scid, IL-2Rγnull) マウス”（Ito M et al., Blood 2002）の樹立に成功しました。

NOGマウスはヒト細胞、ヒト組織の生着性がNOD-scidマウスと比べて著しく高く、ヒト癌細胞やヒト肝臓細胞を高率に生着させることが可能であります。またヒト造血幹細胞移植後に、NOD-scidマウスでは見られなかったヒトT細胞の分化が末梢リンパ組織で認められることから、ヒト免疫系モデルマウスとしての需要も高まってきております。

NOGマウスの特徴

  • T, B細胞の欠失
  • ナチュラルキラー（NK）細胞の欠失
  • 樹状細胞機能の低下
  • マクロファージ機能の低下
  • 補体活性の欠失
  • 老化に伴うT, B細胞leaknessが認められない
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追加情報

NOGマウスを用いた主なヒト化モデル

ヒト肝臓モデル

NOGマウスの飼育管理について

文献集

2019年
  1. Humanized mice as an effective evaluation system for peptidevaccines and immune checkpoint inhibitors.
    Kametani Y, Ohno Y, Ohshima S, Tsuda B, Yasuda A, Seki T, Ito R, Tokuda Y.
    Int J Mol Sci. 2019 Dec 16;20(24)
  2. Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver.
    Ogawa SI, Uehara S, Tsunenari Y, Kawai H, Suemizu H, Yamazaki H.
    Xenobiotica. 2019 Nov 25:1-7
  3. Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse.
    Ashizawa T, Iizuka A, Tanaka E, Kondou R, Miyata H, Maeda C, Sugino T, Yamaguchi K, Ando T, Ishikawa Y, Ito M, Akiyama Y.
    Biomed Res. 2019;40(6):243-250
  4. Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.
    Ashizawa T, Iizuka A, Maeda C, Tanaka E, Kondou R, Miyata H, Sugino T, Kawata T, Deguchi S, Mitsuya K, Hayashi N, Asai A, Ito M, Yamaguchi K, Akiyama Y.
    Immunol Lett. 2019 Dec;216:43-50
  5. A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers.
    Kamimura H, Uehara S, Suemizu H.
    Xenobiotica. 2019 Nov 22:1-8
  6. Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.
    Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.
    Xenobiotica. 2019 Nov 12:1-8
  7. Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver.
    Iwata H, Goto M, Sakai N, Suemizu H, Yamazaki H.
    Xenobiotica. 2019 Nov;49(11):1311-1322
  8. Exacerbation of pathogenic Th17-cell-mediated cutaneous graft-versus-host-disease in human IL-1β and IL-23 transgenic humanized mice.
    Ito R, Katano I, Otsuka I, Hanazawa A, Takahashi T, Kawai K, Yagoto M, Goto M, Ogura T, Takahashi R, Ito M.
    Biochem Biophys Res Commun. 2019 Aug 20;516(2): 480-485
  9. Recent Advances in Allergy Research Using Humanized Mice.
    Ito R, Maruoka S, Gon Y, Katano I, Takahashi T, Ito M, Izuhara K, Nunomura S.
    Int J Mol Sci. 2019 Jun 4;20(11)
  10. Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice.
    Doi A, Hikita H, Kai Y, Tahata Y, Saito Y, Nakabori T, Yamada R, Kodama T, Sakamori R, Murayama A, Nitta S, Asahina Y, Suemizu H, Tatsumi T, Kato T, Takehara T.
    J Gastroenterol. 2019 May;54(5):449-458
  11. Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice.
    Mathews S, Branch Woods A, Katano I, Makarov E, Thomas MB, Gendelman HE, Poluektova LY, Ito M, Gorantla S.
    Mol Neurodegener. 2019 Mar 5;14(1):12
2018年
  1. A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis.
    Ito R, Maruoka S, Soda K, Katano I, Kawai K, Yagoto M, Hanazawa A, Takahashi T, Ogura T, Goto M, Takahashi R, Toyoshima S, Okayama Y, Izuhara K, Gon Y, Hashimoto S, Ito M, Nunomura S.
    JCI Insight.,2018 Nov 2;3(21)
  2. Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6.
    Uehara S, Murayama N, Yamazaki H, Suemizu H.
    Xenobiotica. 2019 Nov;49(11):1323-1331
  3. Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice.
    Aono S, Tatsumi T, Yoshioka T, Tawara S, Nishio A, Onishi Y, Fukutomi K, Nakabori T, Kodama T, Shigekawa M, Hikita H, Sakamori R, Takahashi T, Suemizu H, Takehara T.
    Biochem Biophys Res Commun. 2018 Sep 10;503(3):1457-1464
  4. Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA.
    Murayama N, Suemizu H, Uehara S, Kusama T, Mitsui M, Kamiya Y, Shimizu M, Guengerich FP, Yamazaki H.
    J Toxicol Sci. 2018;43(6):369-375
  5. Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice.
    Shimizu M, Suemizu H, Mizuno S, Kusama T, Miura T, Uehara S, Yamazaki H.
    J Toxicol Sci. 2018;43(6):387-393
  6. Comprehensive Analysis of the Activation and Proliferation Kinetics and Effector Functions of Human Lymphocytes, and Antigen Presentation Capacity of Antigen-Presenting Cells in Xenogeneic Graft-Versus-Host Disease.
    Kawasaki Y, Sato K, Hayakawa H, Takayama N, Nakano H, Ito R, Mashima K, Oh I, Minakata D, Yamasaki R, Morita K, Ashizawa M, Yamamoto C, Hatano K, Fujiwara SI, Ohmine K, Muroi K, Kanda Y.
    Biol Blood Marrow Transplant. 2018 Aug;24(8):1563-1574
  7. Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers.
    Uehara S, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H.
    Xenobiotica. 2019 Jun;49(6):678-687
  8. Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice.
    Hanazawa A, Ito R, Katano I, Kawai K, Goto M, Suemizu H, Kawakami Y, Ito M, Takahashi T.
    Front Immunol. 2018 Feb 2;9:152
  9. Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis.
    Takahashi T, Katano I, Ito R, Goto M, Abe H, Mizuno S, Kawai K, Sugiyama F, Ito M.
    Front Immunol. 2018 Jan 17;8:2017
2017年
  1. Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse.
    Katano I, Nishime C, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M, Takahashi T.
    Scientific Reports, 2017 Dec 8;7(1):17230,17442-7
  2. Human PBMC-transferred murine MHC classI/II-deficient NOG mice enable long-term evaluation of human immune responses.
    Yaguchi T, Kobayashi A, Inozume T, Morii K, Nagumo H, Nishio H, Iwaata T, Ka Y, Katano I, Ito R, Ito M, Kawakami Y.
    Cellular and Molecular Immunology, 2018 Nov;15(11):953-962
  3. A novel in vivo model for predicting myelotoxicity of chemotherapeutic agents using IL-3/GM-CSF transgenic humanized mice.
    Ito R, Nagai D, Igo N, Okuda Y, Sekine K, Ichimura E, Katano I, Mizushima T, Goto M, Ohnishi Y, Ito M, Okamoto K.
    Toxicology Letter, 2017 Nov 5; 281:152-157
  4. NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination.
    Kametani Y, Katano I, Miyamoto A, Kikuchi Y, Ito R, Muguruma Y, Tsuda B, Habu S, Tokuda Y, Ando K, Ito M.
    PLoS One, 2017 Jun 15;12(6):e0179239
  5. The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line.
    Akiyama Y, Nonomura C, Ashizawa T, Iizuka A, Kondou R, Miyata H, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Asai A, Ito M, Kiyohara Y, Yamaguchi K. Immunol Lett, 2017 Oct;190:20-25
  6. Human Plasma Metabolic Profiles of Benzydamine, a Flavin-containing Monooxygenase Probe Substrate, Simulated with Pharmacokinetic Data from Control and Humanized-liver Mice.
    Yamazaki-Nishioka M, Shimizu M, Suemizu H, Nishiwaki M, Mitsui M, Yamazaki H. Xenobiotica, 2018 Feb;48(2):117-123
  7. A recombinant vesicular stomatitis virus encoding CCR5-tropic HIV-1 receptors targets HIV-1-infected cells and controls HIV-1 infection.
    Okuma K, Fukagawa K, Kohma T, Takahama Y, Hamaguchi Y, Ito M, Tanaka Y, Buonocore L, Rose J. K, Hamaguchi I.
    Microbes Infect, 2017 Apr-May;19(4-5):277-287
  8. Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling.
    Muguruma Y, Hozumi K, Warita H, Yahata T, Uno T, Ito M, Ando K.
    J Cell Physiol, 2017 Sep;232(9):2569-2580
  9. A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice.
    Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M.
    Am J Transplant, 2017 May;17(5):1216-1228
  10. 10. Antitumor effect of programmed death-1 (PD-1) blockade in humanized the NOG-major histocompatibility complex (MHC) double knockout mouse.
    Ashizawa T, Iizuka A, Nonomura C, Kondou R, Maeda C, Miyata H, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Maruyama K, Yamaguchi K, Katano I, Ito M, Akiyama Y.
    Clin Cancer Res, 2017 Jan;23(1):149-156
2016年
  1. Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.
    Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H.
    Xenobiotica. 2016; Nov 16:1-5
  2. Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
    Kamimura H, Ito S, Chijiwa H, Okuzono T, Ishiguro T, Yamamoto Y, Nishinoaki S, Ninomiya SI, Mitsui M, Kalgutkar AS, Yamazaki H, Suemizu H.
    Xenobiotica. 2016 Jul 7:1-12
  3. Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver.
    Nakabori T, Hikita H, Murai K, Nozaki Y, Kai Y, Makino Y, Saito Y, Tanaka S, Wada H, Eguchi H, Takahashi T, Suemizu H, Sakamori R, Hiramatsu N, Tatsumi T, Takehara T.
    Sci Rep. 2016;6:27782
  4. Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.
    Utoh M, Suemizu H, Mitsui M, Kawano M, Toda A, Uehara S, Uno Y, Shimizu M, Sasaki E, Yamazaki H.
    Xenobiotica. 2016; Dec 46(12):1049-1055
  5. Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.
    Higuchi Y, Kawai K, Kanaki T, Yamazaki H, Chesné C, Guguen-Guillouzo C, Suemizu H.
    Hepatol Res. 2016; 46(10):1045-57
  6. 「ヒト化マウス」
    伊藤守
    マウス表現型解析スタンダード, 56-62, 2016
2015年
  1. The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.
    Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T.
    PLoS One. 2015; 10(12):e0144775
  2. Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.
    Nishiyama S, Suemizu H, Shibata N, Guengerich FP, Yamazaki H.
    Chem Res Toxicol. 2015; 28(11):2088-90
  3. Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.
    Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T.
    J Gastroenterol. 2015; 50(11):1145-51
  4. Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.
    Soulard V, Bosson-Vanga H, Lorthiois A, Roucher C, Franetich JF, Zanghi G, Bordessoulles M, Tefit M, Thellier M, Morosan S, Le Naour G, Capron F, Suemizu H, Snounou G, Moreno-Sabater A, Mazier D. Nat Commun. 2015 Jul 24;6:7690
  5. Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.
    Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.
    J Immunol. 2015; 195(4):1883-90
  6. Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.
    Chijiwa T, Kawai K, Noguchi A, Sato H, Hayashi A, Cho H, Shiozawa M, Kishida T, Morinaga S, Yokose T, Katayama M, Takenaka N, Suemizu H, Yamada R, Nakamura Y, Ohtsu T, Takano Y, Imai K, Miyagi Y, Nakamura M.
    Int J Oncol. 2015; 47(1):61-70
  7. Visualization of the human CD4(+) T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/gammac(null) (NOG) mice by retrogenic expression of the human TCR gene
    Takahashi T, Katano I, Ito, R, Ito M.
    Biochem Biophys Res Commun 2015; 456(1):219-224
  8. Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse
    Katano I, Takahashi T, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M.
    J Immunol 2015; 194(7):3513-3525
  9. Role of Mouse Inanate Immunity in Immunodeficient Mice for Xenotransplantation.
    Ito R, Katano I, Ito M.
    ed^eds. 25-32 Springer, New York. 2015
  10. Mamoru Ito's Vision for the Future of Humanized Mouse Models.
    Ito M.
    ed^eds. 1-12 Springer, New York. 2015
  11. The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice. Fujii E, Kato A, Chen YJ, Matsubara K, Ohnishi Y, Suzuki M.
    Exp Anim. 2015; 64(2):181-90
  12. Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers.
    Kamimura H, Ito S, Nozawa K, Nakamura S, Chijiwa H, Nagatsuka S, Kuronuma M, Ohnishi Y, Suemizu H, Ninomiya S.
    Drug Metab Dispos. 2015; 43(3):309-16
  13. 「ヒト化マウス創出をめざした免疫不全マウスの開発研究」
    伊藤守
    LABIO21, 61: 20-23, 2015
  14. 「ヒト化マウスを用いたヒトアレルギーモデルの開発」 伊藤亮治
    アレルギーの臨床 478: 54-58, 2015
2014年
  1. APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model
    Sato K, Takeuchi J. S, Misawa N, Izumi T, Kobayashi T, Kimura Y, Iwami S, Takaori-Kondo A, Hu W. S, Aihara K, Ito M, An D. S, Pathak V. K, Koyanagi Y.
    PLoS Pathog 2014; 10(10):e1004453
  2. Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1
    Negishi N, Suzuki D, Ito R, Irie N, Matsuo K, Yahata T, Nagano K, Aoki K, Ohya K, Hozumi K, Ando K, Tamaoki N, Ito M, Habu S.
    Exp Hematol 2014; 42(6):487-494
  3. Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice
    Matsushita H, Yahata T, Sheng Y, Nakamura Y, Muguruma Y, Matsuzawa H, Tanaka M, Hayashi H, Sato T, Damdinsuren A, Onizuka M, Ito M, Miyachi H, Pandolfi P. P, Ando K.
    PLoS One 2014; 9(11):e111082
  4. NOD-Rag2(null) IL-2Rgamma(null) Mice: An Alternative to NOG Mice for Generation of Humanized Mice
    Katano I, Ito R, Kamisako T, Eto T, Ogura T, Kawai K, Suemizu H, Takahashi T, Kawakami Y, Ito M.
    Exp Anim 2014; 63(3):321-330
  5. Characterization of EBV-related lymphoproliferative lesions arising in donor lymphocytes of transplanted human tumor tissues in the NOG mouse.
    Fujii E, Kato A, Chen YJ, Matsubara K, Ohnishi Y, Suzuki M.
    Exp Anim. 2014; 63(3):289-96
  6. Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice.
    Suemizu H, Nakamura K, Kawai K, Higuchi Y, Kasahara M, Fujimoto J, Tanoue A, Nakamura M.
    Liver Transpl. 2014; 20(9):1127-37
  7. Novel enhanced green fluorescent protein-expressing NOG mouse for analyzing the microenvironment of xenograft tissues.
    Higuchi Y, Kawai K, Yamamoto M, Kuronuma M, Ando Y, Katano I, Nakamura M, Suemizu H.
    Exp Anim. 2014; 63(1):55-62
  8. Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.
    Gutti TL, Knibbe JS, Makarov E, Zhang J, Yannam GR, Gorantla S, Sun Y, Mercer DF, Suemizu H, Wisecarver JL, Osna NA, Bronich TK, Poluektova LY.
    Am J Pathol. 2014; 184(1):101-9
  9. Effect of in vivo administration of reprogramming factors in the mouse liver.
    Tomokuni A, Eguchi H, Hoshino H, Dewi DL, Nishikawa S, Kano Y, Miyoshi N, Tojo A, Kobayashi S, Gotoh N, Hinohara K, Fusaki N, Saito T, Suemizu H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Doki Y, Mori M, Ishii H, Nagano H.
    Oncol Lett. 2013; 6(2):323-328
  10. The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.
    Higuchi Y, Kawai K, Yamazaki H, Nakamura M, Bree F, Guguen-Guillouzo C, Suemizu H.
    Xenobiotica. 2014; 44(2):146-53
  11. 「実験動物の温故知新　第2回　ヒト化マウスの開発に至るまで」
    伊藤守
    実験医学 32: 1298−1301, 2014
  12. 「ヒト化マウス国際ワークショップについて」
    伊藤守
    LABIO21, 56: 28-29, 2014
2013年
  1. HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4(+) T Cells In Vivo
    Sato K, Misawa N, Iwami S, Satou Y, Matsuoka M, Ishizaka Y., Ito M., Aihara K., An D. S, Koyanagi, Y.
    PLoS Pathog 2013; 9(12):e1003812
  2. Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome
    Saida S, Watanabe K, Sato-Otsubo A, Terui K, Yoshida K, Okuno Y, Toki T, Wang R, Shiraishi Y, Miyano S, Kato I, Morishima T, Fujino H, Umeda K, Hiramatsu H, Adachi S, Ito E, Ogawa S, Ito M, Nakahata T, Heike T.
    Blood 2013; 121(21):4377-4387
  3. Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice
    Ito R, Takahashi T, Katano I, Kawai K, Kamisako T, Ogura T, Ida-Tanaka M, Suemizu H, Nunomura S,
    Ra C, Mori A, Aiso S, Ito M. J Immunol 2013; 191(6):2890-2899
  4. Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells
    Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K.
    Stem Cell Reports 2013; 1(6):499-508
  5. Identification of an astrovirus commonly infecting laboratory mice in the US and Japan. Ng TF, Kondov NO,
    Hayashimoto N, Uchida R, Cha Y, Beyer AI, Wong W, Pesavento PA, Suemizu H, Muench MO, Delwart E.
    PLoS One. 2013; 8(6):e66937
  6. In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.
    Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP.
    Chem Res Toxicol. 2013; 26(3):486-9
  7. Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. Tsukada A, Suemizu H, Murayama N, Takano R, Shimizu M, Nakamura M, Yamazaki H.
    Regul Toxicol Pharmacol. 2013; 65(3):316-24
2012年
  1. A new in vivo model to analyze hepatic metastasis of the human colon cancer cell line HCT116 in NOD/Shi-scid/IL-2Rγ(null) (NOG) mice by (18)F-FDG PET/CT.
    Kawai K, Tamura K, Sakata I, Ishida J, Nagata M, Tsukada H, Suemizu H, Nakamura M, Abe Y, Chijiwa T.
    Oncol Rep. 2013; 29(2):464-8
  2. CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model.
    Zhang Y, Patel S, Abdelouahab H, Wittner M, Willekens C, Shen S, Betems A, Joulin V, Opolon P, Bawa O, Pasquier F, Ito M, Fujii N, Gonin P, Solary E, Vainchenker W, Coppo P, De Botton S, Louache F.
    Cell Death Dis. 2012 Oct 4;3:e396
  3. Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells.
    Ito R, Katano I, Ida-Tanaka M, Kamisako T, Kawai K, Suemizu H, Aiso S, Ito M.
    J Immunol. 2012; 189(9):4313-20
  4. Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts.
    Ito R, Negishi N, Irie N, Matsuo K, Suzuki D, Katano I, Hayakawa E, Kawai K, Kamisako T, Eto T, Ogura T, Hozumi K, Ando K, Aiso S, Tamaoki N, Habu S, Ito M.
    Exp Hematol. 2012; 40(11):953-963
  5. Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse.
    Suzuki M, Takahashi T, Katano I, Ito R, Ito M, Harigae H, Ishii N, Sugamura K.
    Int Immunol. 2012; 24(4):243-52
  6. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.
    Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP.
    Chem Res Toxicol. 2012; 25(2):274-6
  7. T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γcnull mice.
    Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H.
    Cancer Sci. 2012; 103(1):17-25
  8. 「ヒト化マウスの改良と疾患モデルへの応用」
    伊藤守、末水洋志
    実験医学 30: 154-159, 2012
2011年
  1. Epstein-Barr virus induces erosive arthritis in humanized mice.
    Kuwana Y, Takei M, Yajima M, Imadome K, Inomata H, Shiozaki M, Ikumi N, Nozaki T, Shiraiwa H, Kitamura N, Takeuchi J, Sawada S, Yamamoto N, Shimizu N, Ito M, Fujiwara S.
    PLoS One. 2011; 6(10):e26630
  2. Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
    Yahata T, Takanashi T, Muguruma Y, Ibrahim A. A, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K.
    Blood 2011; 118(11):2941-2950
  3. A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice
    Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y.
    Blood 2011; 117(21):5663-5673
  4. Identification of Hepatic Niche Harboring Human Acute Lymphoblastic Leukemic Cells via the SDF-1/CXCR4 Axis
    Kato I, Niwa A, Heike T, Fujino H, Saito M. K, Umeda K, Hiramatsu H, Ito M, Morita M, Nishinaka Y, Adachi S, Ishikawa F, Nakahata T.
    PLoS One 2011; 6(11):e27042
  5. Detection of the Onset of Ischemia and Carcinogenesisby Hypoxia-Inducible Transcription Factor-Based In Vivo Bioluminescence Imaging
    Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y, Murakami A, Tani T, Watanabe H, Tanaka T, Hirota K, Inoue M, Tsukamoto T, Toyoda T, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S.
    PLos One 2011; 6(11):e26640
  6. Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-infected T and NK cells
    Imadome K, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura O, Komano J, Fujiwara S.
    PLoS Pathog 2011; 7(10):e1002326
  7. 「ヒト化NOGマウス」
    伊藤守
    モデル動物利用マニュアルシリーズ：生体機能モデルと新しいリソース・リサーチツール　423-431, 2011
  8. 「免疫不全モデル：Ｔ細胞」
    伊藤守
    モデル動物利用マニュアルシリーズ：疾患モデルの作製と利用—免疫疾患　129-132, 2011
  9. The Reconstituted 'Humanized Liver' in TK-NOG Mice is Mature and Functional
    Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H
    Biochem Biophys Res Commun. 2011 Jan 13
  10. Immunodeficient NOD-scid IL-2Rgnull Mice Do Not Display T and B cell Leakness
    Katano I, Ito R, Eto T, Aiso S, Ito M
    Exp. Anim. 60(2), 181-186, 2011
  11. 「ヒト化マウスの現状と将来展望」
    伊藤守
    MDS (Medical Science Digest) vol. 37, 44-45

  12. Establishment of a xenograft model of human myelodysplastic syndromes
    Muguruma, Y., H. Matsushita, T. Yahata, S. Yumino, Y. Tanaka, H. Miyachi, Y. Ogawa, H. Kawada, M. Ito, and K. Ando Haemato
    logica 96:543-551 2011

  13. Mismatched HLA class II-restricted CD8(+) cytotoxic T-cells may serve selective GVL effects following allogeneic hematopoietic cell transplantation
    Hirosawa, T., H. Torikai, M. Yanagisawa, M. Kamei, N. Imahashi, A. Demachi-Okamura, M. Tanimoto, K. Shiraishi, M. Ito, K. Miyamura, K. Shibata, F. Kikkawa, Y. Morishima, T. Takahashi, N. Emi, K. Kuzushima, and Y. Akatsuka
    Cancer Sci Apr 5 2011
2010年
  1. Multiple integrations of human T-lymphotropic virus type 1 proviruses in the engrafted cells from the asymptomatic carriers in NOD/SCID/gammacnull mice
    Yamamoto I, Takajo I, Umeki K, Morishita K, Hatakeyama K, Kataoka H, Nomura H, Okayama A
    Intervirology. 2010;53(4):229-39
  2. Establishment of long-term model throughout regular menstrual cycles in immunodeficient mice
    Kikuchi-Arai M, Murakami T, Utsunomiya H, Akahira J, Suzuki-Kakisaka H, Terada Y, Tachibana M, Hayasaka S, Ugajin T, Yaegashi N
    Am J Reprod Immunol. 2010 Nov;64(5):324-32
  3. Development of humanized models using NOG mice
    Wakui M, Suemizu H
    Seikagaku. 2010 Apr;82(4):314-8. Japanese
  4. Dynamics of memory and nalve CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1
    Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y
    Vaccine. 2010 May 26;28 Suppl 2:B32-7
  5. In vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice
    Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N
    Biochem Biophys Res Commun. 2010 Sep 3;399(4):733-7
  6. Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines
    Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, Fukushima K, Shiina M, Yamagiwa Y, Kondo Y, Inoue J, Kakazu E, Iwasaki T, Kawagishi N, Shimosegawa T, Sugamura K
    Cancer Sci. 2010 Oct;101(10):2145-55
  7. Establishment of a novel xenograft model for human uterine leiomyoma in immunodeficient mice
    Tsuiji K, Takeda T, Li B, Kondo A, Ito M, Yaegashi N
    Tohoku J Exp Med. 2010;222(1):55-61
  8. 「ヒト化マウスの現状」
    伊藤守
    細胞工学　29, 238-242, 2010
2009年
  1. Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice
    Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T
    Biochem Biophys Res Commun. 2009 Jan 16;378(3):467-72
  2. Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model
    Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
    Cancer Immunol Immunother. 2009 Aug;58(8):1195-206
  3. In vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells
    Kai M, Hagiwara T, Emuta C, Chisaka Y, Tsuruhata K, Endo C, Inagaki Y, Miyazaki H, Kataoka S
    Blood. 2009 Mar 5;113(10):2213-6
  4. Thrombospondin 2 inhibits metastasis of human malignant melanoma through microenvironment-modification in NOD/SCID/gammaCnull (NOG) mice
    Chijiwa T, Abe Y, Ikoma N, Yamazaki H, Tsukamoto H, Suemizu H, Kawai K, Wakui M, Nishime C, Matsumoto H, Matsuyama M, Mukai M, Ueyama Y, Nakamura M
    Int J Oncol. 2009 Jan;34(1):5-13
  5. Ectopic porcine spermatogenesis in murine subcutis: tissue grafting versus cell-injection methods
    Watanabe T, Hayashi H, Kita K, Kubota Y, Ogawa T
    Asian J Androl. 2009 May;11(3):317-23
  6. Variation in the incidence of teratomas after the transplantation of nonhuman primate ES cells into immunodeficient mice
    Kishi Y, Tanaka Y, Shibata H, Nakamura S, Takeuchi K, Masuda S, Ikeda T, Muramatsu S, Hanazono Y
    Cell Transplant. 2008;17(9):1095-102
  7. Effects of liposome-encapsulated hemoglobin on human immune system: evaluation in immunodeficient mice reconstituted with human cord blood stem cells
    Kawaguchi AT, Kametani Y, Kato S, Furuya H, Tamaoki K, Habu S
    Artif Organs. 2009 Feb;33(2):169-76
  8. Higher susceptibility of NOG mice to xenotransplanted tumors
    Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T
    J Toxicol Sci. 2009 Feb;34(1):123-7
  9. Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice
    Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M
    Transplantation. 2009 Jun 15;87(11):1654-8
  10. Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2R gamma (null) mouse
    Kato C, Fujii E, Chen YJ, Endaya BB, Matsubara K, Suzuki M, Ohnishi Y, Tamaoki N
    Lab Anim. 2009 Oct;43(4):402-4
  11. The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice)
    Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K
    Int Immunol. 2009 Jul;21(7):843-58
  12. ERas is expressed in primate embryonic stem cells but not related to tumorigenesis
    Tanaka Y, Ikeda T, Kishi Y, Masuda S, Shibata H, Takeuchi K, Komura M, Iwanaka T, Muramatsu S, Kondo Y, Takahashi K, Yamanaka S, Hanazono Y
    Cell Transplant. 2009;18(4):381-9
  13. An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice
    Inoue M, Senju S, Hirata S, Irie A, Baba H, Nishimura Y
    Immunol Lett. 2009 Sep 22;126(1-2):67-72
  14. Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo
    Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
    J Immunol. 2009 Oct 1;183(7):4782-91
  15. T cell-mediated control of Epstein-Barr virus infection in humanized mice
    Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Yamamoto N, Fujiwara S
    J Infect Dis. 2009 Nov 15;200(10):1611-5
  16. 「NOGマウスとヒト化マウス」
    伊藤守
    ファルマシア　45, 1077-1081, 2009
2008年
  1. Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice
    Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H
    J Oncol., 32:153-159., 2008
  2. Interleukin-4-Transgenic hu-PBL-SCID Mice: A Model for the Screening of Antiviral Drugs and Immunotherapeutic Agents against X4 HIV-1 Viruses
    Okuma K, Tanaka R, Ogura T, Ito M, Kumakura S, Yanaka M, Nishizawa M, Sugiura W, Yamamoto N, Tanaka Y
    J Infect Dis197:134-141
  3. Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells
    Ochiai T, Saito Y, Saitoh T, Dewan MZ, Shioya A, Kobayashi M, Kawachi H, Muto S, Itai A, Uota S, Eishi Y, Yamamoto N, Tanaka S, Arii S, Yamaoka S
    J Med Dent Sci. 2008 Mar;55(1):49-59
  4. Basic concept of development and practical application of animal models for human diseases
    Nomura T, Tamaoki N, Takakura A, Suemizu H
    Curr Top Microbiol Immunol. 2008;324:1-24
  5. NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models
    Ito M, Kobayashi K, Nakahata T
    Curr Top Microbiol Immunol. 2008;324:53-76
  6. Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system
    Ito R, Shiina M, Saito Y, Tokuda Y, Kametani Y, Habu S
    Curr Top Microbiol Immunol. 2008;324:95-107
  7. Humanized mice for human retrovirus infection
    Koyanagi Y, Tanaka Y, Ito M, Yamamoto N
    Curr Top Microbiol Immunol. 2008;324:133-48
  8. Novel metastasis models of human cancer in NOG mice
    Nakamura M, Suemizu H
    Curr Top Microbiol Immunol. 2008;324:167-77
  9. Humanizing bone marrow in immune-deficient mice
    Ando K, Muguruma Y, Yahata T
    Curr Top Microbiol Immunol. 2008;324:77-86
  10. Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes
    Yamane A, Nakamura T, Suzuki H, Ito M, Ohnishi Y, Ikeda Y, Miyakawa Y
    Blood. 2008 Aug 1;112(3):542-50
  11. A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses
    Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Honda M, Yamamoto N, Fujiwara S
    J Infect Dis. 2008 Sep 1;198(5):673-82
  12. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis
    Nogami W, Yoshida H, Koizumi K, Yamada H, Abe K, Arimura A, Yamane N, Takahashi K, Yamane A, Oda A, Tanaka Y, Takemoto H, Ohnishi Y, Ikeda Y, Miyakawa Y
    Haematologica. 2008 Oct;93(10):1495-504
  13. Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice
    Suemizu H, Hasegawa M, Kawai K, Taniguchi K, Monnai M, Wakui M, Suematsu M, Ito M, Peltz G, Nakamura M
    Biochem Biophys Res Commun. 2008 Dec 5;377(1):248-52
  14. Establishing EGFP congenic mice in a NOD/Shi-scid IL2Rg(null) (NOG) genetic background using a marker-assisted selection protocol (MASP)
    Suemizu H, Yagihashi C, Mizushima T, Ogura T, Etoh T, Kawai K, Ito M
    Exp Anim. 2008 Oct;57(5):471-7
  15. Development of human Graafian follicles following transplantation of human ovarian tissue into NOD/SCID/gammac null mice
    Terada Y, Terunuma-Sato Y, Kakoi-Yoshimoto T, Hasegawa H, Ugajin T, Koyanagi Y, Ito M, Murakami T, Sasano H, Yaegashi N, Okamura K
    Am J Reprod Immunol. 2008 Dec;60(6):534-40
2007年
  1. Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses
    Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N
    Blood, 109:212-218.,2007
  2. Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice
    Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T
    Leukemia, 21:136-142., 2007
  3. Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel new quantitative model of metastasis in NOD/SCID/gcnull (NOG) mice
    Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M
    International J Oncology, Oct;31(4):741-51.,2007
  4. IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells
    Watanabe M, Dewan MZ, Taira M, Shoda M, Honda M, Sata T, Higashihara M, Kadin ME, Watanabe T, Yamamoto N, Umezawa K, Horie R
    Lab Invest, 87:372-382., 2007
  5. Humanized NOD/SCID/IL2R{gamma}null Mice Transplanted with Hematopoietic Stem Cells under non-Myeloablative Condition Show Analysis of HIV-1 Pathogenesis
    Watanabe S, Ohta S, Yajima M, Terashima K, Ito M, Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N, Yamamoto N
    J Virol, 13259-13264., 2007
  6. Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c(null) immunodeficient mice
    Masuda H, Maruyama T, Hiratsu E, Yamane J, Iwanami A, Nagashima T, Ono M, Miyoshi H, Okano HJ, Ito M, Tamaoki N, Nomura T, Okano H, Matsuzaki Y, Yoshimura Y
    Proc Natl Acad Sci U S A., 104:1925-1930., 2007
  7. Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells
    Ono, M, Maruyama T, Masuda H, Kajitani T, Nagashima T, Arase T, Ito M, Ohta K, Uchida H, Asada H, Yoshimura Y, Okano H, Matsuzaki Y
    Proc Natl Acad Sci U S A., 104., 2007
  8. Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion
    Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T
    Faseb, J, 21:3499-3510., 2007
  9. Angiopoietin-1 supports induction of hematopoietic activity in human CD34- bone marrow cells
    Nakamura Y, Yahata T, Muguruma Y, Uno T, Sato T, Matsuzawa H, Kato S, Shirasugi Y, Hotta T, Ando K
    Exp Hematol. 2007 Dec;35(12):1872-83
2006年
  1. Identification of human neutrophils during experimentally induced inflammation in mice with transplanted CD34+ cells from human umbilical cord blood
    Doshi, M., M. Koyanagi, M. Nakahara, K. Saeki, K. Saeki, and A. Yuo
    Int J Hematol 84:231-237.,2006
  2. A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis
    Takanori Nakamura, Yoshitaka Miyakawa, Atsushi Miyamura, Akiko Yamane, Hidenori Suzuki, Mamoru Ito, Yasuyuki Ohnishi, Norihisa Ishiwata, Yasuo Ikeda, Nobutomo Tsuruzoe
    Blood, 107(11):4300-4307, 2006
  3. Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells
    Yahata T, Yumino S, Seng Y, Miyatake H, Uno T, Muguruma Y, Ito M, Miyoshi H, Kato S, Hotta T, Ando K
    Blood, 108:2446-2454.,2006
  4. Development of human-human hybridoma from anti-Her-2 peptide-producing B cells in immunized NOG mouse
    Kametani Y, Shiina M, Katano I, Ito R, Ando K, Toyama K, Tsukamoto H, Matsumura T, Saito Y, Ishikawa D, Taki T, Ito M, Imai K, Tokuda Y, Kato S,Tamaoki N, Habu S
    Exp Hematol, 34:1239-1247, 2006
  5. Efficient intervention of growth and infiltration of primary adult T-cell leukemia cell by an HIV protease inhibitor, ritonavir
    M.Zahidunnabi Dewan, Jun-nosuke Uchihara, Kazuo Terashima, Mitsuo Honda, Tetsutaro Sata, Mamoru Ito, Nobutaka Fujii, Kimiharu Uozumi, Kunihiro Tsukasaki, Masao Tomonaga, Yoko Kubuki, Akihiko Okayama, Masakazu Toi, Naoki Mori, Naoki Yamamoto
    Blood,107(2):716-724, 2006
  6. Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene
    Manabu Ninomiya, Akihiro Abe, Toshiy Yokozawa, Kazutaka Ozeki, Kazuhito Yamamoto, Mamoru Ito, Masafumi Ito, Hitoshi Kiyoi, Nobuhiro Emi, Tomoki Naoe
    Cancer Genetics Cytogenetics,169:1-11,2006
  7. Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment
    Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J, Kato S, Ito M, Hotta T, Ando K
    Blood, 107:1878-1887., 2006
  8. Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells
    Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N
    Cancer Sci, 97:1381-1387.,2006
  9. Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo
    Dewan MZ, Terunuma H, Takada M, Tanaka Y, Abe H, Sata T, Toi M, Yamamoto N
    Breast Cancer Res Treat, 2006
2005年
  1. S100A4 Expression with Reduced E-cadherin Expression Predicts Distant Metastasis of Human Malignant Melanoma Cell Lines in the NOD/SCID/γcnull (NOG) Mouse Model
    Norihiro Ikoma, Hitoshi Yamazaki, Yoshiyuki Abe, Yasuhisa Oida, Yasuyuki Ohnishi, Hiroshi Suemizu, Hozumi Matsumoto, Takashi Matsuyama, Yukinori Ohta, Akira Ozawa, Yoshito Ueyama, Masato Nakamura
    Oncology Reports, 14:633-637,2005
  2. Hodgkin's Lymphoma Cells are Efficiently Engrafted and Tumor Marker CD30 is Expressed with Constitutive Nuclear Factor-кB Activity in Unconditioned NOD/SCID/γcnull Mice
    Md.Zahidunnabi Dewan, Mariko Watanabe, Sunjida Ahmed, Kazuo Terashima, Sankichi Horiuchi, Tetsutaro Sata, Mitsuo Honda, Mamoru Ito, Toshiki Watanabe, Ryouichi Horie, Naoki Yamamoto
    Cancer Sci., 96(8):466-473,2005
  3. Potent Anti-R5 Human Immunodeficiency Virus Type 1 Effects of a CCR5 Antagonist, AK602/ONO4128/GW873140, in a Novel Human Peripheral Blood Mononuclear Cell Nonobese Diabetic-SCID, Interleukin-2 Receptor
    Hirotomo Nakata, Kenji Maeda, Toshikazu Miyakawa, Shiro Shibuyama, Masayoshi Matsuo, Yoshikazu Takaoka, Mamoru Ito, Yoshio Koyanagi, Hiroaki Mitsuya
    J. Virology, 79(4):2087-2096,2005
  4. Natural killer cells in breast cancer cell growth and metastasisin SCID mice
    Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M, Yamamoto N
    Biomed Pharmacother, 59 Suppl 2:S375-379.,2005
  5. Reproduction of menstrual changes in transplanted human endometrial tissue in immunodeficient mice
    Matsuura-Sawada R, Murakami T, Ozawa Y, Nabeshima H, Akahira J, SatoY, Koyanagi Y, Ito M, Terada Y, Okamura K
    Hum Reprod,20:1477-1484.,2005
2004年
  1. Competitive Repopulation Assay of Two Gene-Marked Cord Blood Units in NOD/SCID/γcnull Mice
    Takashi Yahata, Kiyoshi Ando, Hiroko Miyatake, Tomoko Uno, Tadayuki Sato, Mamoru Ito, Shunichi Kato, Tomomitsu Hotta
    Molecular Therapy, 10(5),2004
  2. Establishment of a New Model of Human Multiple Myeloma Using NOD/SCID/γcnull (NOG) Mice
    Yoshitaka Miyakawa, Yasuyuki Ohnishi, Masashi Tomisawa, Makoto Monnai, Kanoko Kohmura, Yoshito Ueyama, Mamoru Ito, Yasuo Ikeda, Masahiro Kizaki, Masato Nakamura
    BBRC, 313:258-262,2004
  3. Prompt Tumor Formation and Maintenance of Constitutive NF-κB activity of Multiple Myeloma Cells in NOD/SCID/γcnull Mice
    Md.Zahidunnabi Dewan, Mariko Watanabe, Kazuo Terashima, Mizuho Aoki, Tetsutaro Sata, Mitsuo Honda, Mamoru Ito, Shoji Yamaoka, Toshiki Watanabe, Ryouichi Horie, Naoki Yamamoto
    Cancer Sci., 95(7):564-568,2004
  4. Development of both Human Connective Tissue-type and Mucosal-type mast Cells in Mice from Hematopoietic Stem Cells with Identical Distribution Pattern to Human Body
    Naotomo Kambe, Hidefumi Hiramatsu, Mika shimonaka, Hisanori Fujino, Ryuta Nishikomori, Toshio Heike, Mamoru Ito, Kimio Kobayashi, Yoshito Ueyama, Norihisa Matsuyoshi, Yoshiki Miyachi, Tatsutoshi Nakahata
    Blood, 103(3):860-867,2004
  5. Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line
    Ninomiya, M., H. Kiyoi, M. Ito, Y. Hirose, and T. Naoe
    Leukemia., 18:442-448., 2004
  6. Development of multiple immunodeficient NOD/SCID/γc null (NOG) mice and their application on in vivo experimental medicine.
    Ito M
    J. Germfree Life Gnotobiol., 34:18-21., 2004
  7. 「免疫不全NOGマウスを用いたヒト巨核球・血小板造血の解析 」
    宮川義隆、中村隆典、吉田寛、伊藤守
    Molecular Medicine, 41(12),2004
2003年
  1. Complete Reconstitution of Human Lymphocytes from Cord Blood CD34+ Cells Using the NOD/SCID/γcnull Mice Model
    Hidefumi Hiramatsu, Ryuta Nishikomori, Toshio Heike, Mamoru Ito, Kimio Kobayashi, Kenji Katamura, Tatsutoshi Nakahata
    Blood, 102:873-880,2003
  2. Functional CD5+ B Cells Develop Predominantly in the spleen of NOD/SCID/γcnull (NOG) Mice Transplanted either with Human Umbilical Cord Blood, Bone Marrow and Mobilized Peripheral Blood CD34+ Cells
    Takuya Matsumura, Yoshie Kametani, Kiyoshi Ando, Yasuyuki Hirano, Ikumi Katano, Ryoji Ito, Masashi Shiina, Hideo Tsukamoto, Yuki Saito, Yutaka Tokuda, Shunichi Kato, Mamoru Ito, Kazuo Motoyoshi, Sonoko Habu
    Exp. Hematol. 31:789-797,2003
  3. Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/γcnull Mice: Suppression by an Inhibitor against NF-κB
    M.Zahidunnabi Dewan, Kazuo Terashima, Midori Taruishi, Hideki Hasegawa, Mamoru Ito, Yuetsu Tanaka, Naoki Mori, Tetsutaro Sata, Yoshio Koyanagi, Michiyuki Maeda, Yoko Kubuki, Akihiko Okayama, Masahiro Fujii, Naoki Yamamoto
    J. Virology, 77(9):5286-5294,2003
  4. 「異種動物を用いたヒト造血幹細胞の測定」
    平松英文、中畑龍俊
    ファルマシア,39(2):118-122,2003
  5. NOG (NOD/Shi-scid, γcnull) mouse-HIV-1 and HTLV-1infection model using NOG mice allowing an efficient transplantation of human cells
    Ito M, Koyanagi Y, Terashima K, Yamamoto N, Nakahata T, Ueyama Y, Tamaoki N, Nomura T
    Proc. Japanese Society of Aminal Models for Human Diseases, 19:23-30.,2003
2002年
  1. NOD/SCID/γcnull Mouse: an Excellent Recipient Mouse Model for Engraftment Human Cells
    Mamoru Ito, Hidefumi Hiramatsu, Kimio Kobayashi, Kazutomo Suzue, Mariko Kawahata, Kyoji Hioki, Yoshito Ueyama, Yoshio Koyanagi, Kazuo Zugamura, Kohichiro Tsuji, Toshio Heike, Tatsutoshi Nakahata
    Blood, 100(9):3175-3182,2002
  2. The in vivo Development of Human T Cells from CD34+ Cells in the Murine Thymic Environment
    Yuki Saito, Yoshie Kametani, Katsuto Hozumi, Naoko Mochida, Kiyoshi Ando, Mamoru Ito, Tatsuji Nomura, Yataka Tokuda, Hiroyasu Makuuchi, Tomoo Tajima, Sonoko Habu
    Int. Immunology, 14(10):1113-1124,2002
  3. Functional Human T Lymphocyte Development from Cord Blood CD34+ Cells in Nonobese Diabetic/Shi-scid, IL-2 Receptor γ Null Mice
    Takashi Yahata, Kiyoshi Ando, Yoshihiko Nakamura, Yoshito Ueyama, Kazuo Shimamura, Norikazu Tamaoki, Shunichi Kato, Tomomitsu Hotta
    J. Immunology, 169:204-209,2002
  4. 「NOD/SCID/γｃ-/-マウスを用いたヒト造血幹細胞の解析」
    平松英文、中畑龍俊
    Annual Review　血液,2002
2001年
  1. 「ヒューマウスの進歩」
    上山義人、伊藤守
    組織培養工学,27(7),2001
  2. 「NOD/SCIDマウスにおけるヒト造血と免疫の再構築」
    平松英文、中畑龍俊
    分子細胞治療, 2(5),2001
  3. 「HIVモデル動物」
    伊藤守
    総合臨床, 50(10):2693-2695,2001
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