Research

Department of Basic Research for Laboratory Animals

Immunology Laboratory

Immunology Laboratory creates "humanized mice" which harbor human cells and tissues through the development of immunodeficient mice. Severe immunodeficient “NOG” mice developed by CIEA are suitable for reconstituting the human hematopoietic and immune systems. Those “humanized mice” provide unique opportunities to examine various functions or characteristics of human cells in vivo. Immunology laboratory has been developing “more advanced humanized mice” through genetic modifications, which are superior to the parental NOG mice in terms of human hematopoiesis and immune functions. These mice are useful for drug discovery and safety studies.

Immunology Laboratory
免疫研究室

Department of Applied Research for Laboratory Animals

Human Disease Model Laboratory

Human Disease Model Laboratory is developing novel humanized model animals and investigating the pathological mechanisms of immunological and hematological diseases by using these models. Our aim is to apply the humanized model animals for drug discovery research in preclinically and to develop the therapeutics. We also actively collaborate with the researchers in academic institutes, pharmaceutical companies, and etc. to facilitate their basic and translational researches.

Human Disease Model Laboratory
ヒト化モデル研究室

Liver Engineering Laboratory

Liver Engineering Laboratory focuses on the development of liver-humanized mice as an animal experiment model that can be used for research on infectious diseases such as hepatitis virus and malaria and development of new drugs. More than 80% of the liver of a liver-humanized mouse is consisted of human hepatocytes, and it has been revealed that not only expression patterns of drug metabolism related genes and plasma proteins, but also properties of drug metabolism are similar to those in humans.

Liver Engineering Laboratory
バイオメディカル研究室

Tumor Biology Laboratory

Tumor Biology Laboratory has been establishing more than 500 human tumor cell lines (xenografts) since the appearance of nude mice more than 30 years ago and has provided the xenografts to many pharmaceutical companies for screening of anticancer drugs. Most recently, recipient mice have been changed from nude mice to NOG mice and it is now possible to produce xenograft models by transplantation of fewer cancer cells.

Tumor Biology Laboratory
腫瘍研究室

Department of Marmoset Biology and Medicine

Applied Developmental Biology Laboratory

Mice and humans are physiologically and anatomically very different, and cognitive functions such as perception, memory, learning, thinking, and decision are especially different between human and mice. Therefore, non-human primate models that have many physiological features to similar to those in humans are important. We aim to develop a reliable delivery system and safe new drugs and novel therapeutics for patients through developmental engineering and reproductive physiology of the common marmoset, a small primate species.

Applied Developmental Biology Laboratory
応用発生学研究室

Disease Model Animal Laboratory

Animal models of human diseases play a significant role in elucidation of disease mechanisms and the assessment of new drugs and novel therapeutics. The common marmoset, a nonhuman primate species, bridges a gap between humans and rodent laboratory animals. We advance research for the development of disease models and veterinary care for applying common marmosets as human disease models.

Disease Model Animal Laboratory
疾患モデル研究室

Molecular Embryology Laboratory

Creation of transgenic marmosets in 2009 revealed that transgenes can stably function in the body of transgenic marmosets and demonstrated that transgenes are transmitted to progenies. This allowed the creation of disease models by genetic modification using non-human primates.

Molecular Embryology Laboratory
分子発生学研究室

Reproductive Engineering Laboratory

Reproductive Engineering Laboratory is investigating methods for collection, cryopreservation, and individual restoration of germ cells such as oocytes, sperms, and embryos, the origin of biological phenomena. These researches are applied in genome editing and the creation of genetically modified animals.

Reproductive Engineering Laboratory
生殖工学研究室

Live Animal Imaging Center

In in vivo experimental medicine, the ultimate goals of life science are the elucidation of biological functions of humans and triumph over disease. For these goals, we have been developing fundamental technologies over many years. Live Animal Imaging Center performs in vivo imaging using magnetic resonance imaging (MRI), micro X-ray CT, and in vivo fluorescence imaging.

Live Animal Imaging Center
ライブイメージングセンター

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