Molecular Embryology Laboratory
To date, using this technology, genes that cause Alzheimer's disease and Parkinson's disease have been transduced into fertilized eggs of marmosets through viral vectors to generate human disease models in marmosets.
Analysis of these model animals is now ongoing.
Introduction of this technology to create genetically modified marmosets is in demand in Japan as well as in various countries worldwide.
The Molecular Embryology Laboratory is sharing this technology with many researchers globally to facilitate its use.
- Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28.
Tomioka I, Maeda T, Shimada H, Kawai K, Okada Y, Igarashi H, Oiwa R, Iwasaki T, Aoki M, Kimura T, Shiozawa S, Shinohara H, Suemizu H, Sasaki E, Okano H.
Genes Cells. 2010 Sep 1;15(9):959-69.
- Generation of transgenic non-human primates with germline transmission.
Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Tomioka I, Sotomaru Y, Hirakawa R, Eto T, Shiozawa S, Maeda T, Ito M, Ito R, Kito C, Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S, Okano H, Nomura T.
Nature. 2009 May 28;459(7246):523-7.
- Establishment of novel embryonic stem cell lines derived from the common marmoset (Callithrix jacchus).
Sasaki E, Hanazawa K, Kurita R, Akatsuka A, Yoshizaki T, Ishii H, Tanioka Y, Ohnishi Y, Suemizu H, Sugawara A, Tamaoki N, Izawa K, Nakazaki Y, Hamada H, Suemori H, Asano S, Nakatsuji N, Okano H, Tani K.
Stem Cells. 2005 Oct;23(9):1304-13.