Tumor Biology Laboratory | Department of Applied Research for Laboratory Animals
Department of Applied Research for Laboratory Animals
Tumor Biology Laboratory
Tumor Biology Laboratory has established human tumor cell (xenograft) lines for over 30 years since the appearance of the nude mouse and has already established more than 500 xenograft lines.
These xenografts have been provided to many researches for in vivo screening of anticancer drugs.
Most recently, recipient mice have been changed from nude mice to NOG mice and it is now possible to produce xenograft models by transplantation of fewer cancer cells.
Furthermore, liver metastasis models that are difficult to produce with nude mice or SCID (severe combined immunodeficiency) mice can be easily developed with good reproducibility using NOG mice.
They can be used as models for drug efficacy evaluation.
In addition, we revealed that the expression of the discovered factor in this NOG metastasis model is correlated with prognosis of liver metastasis by the analysis of clinical specimens.