Experimental Animals

Next generation immunodeficient mice

List of next generation immunodeficient mice

Human cytokine genes
Strain Features Reference
NOG-hIL-2 Tg Enhanced differentiation into human NK cells Katano I et al. J Immunol 2015
NOG-hGM-CSF/hIL-3 Tg Enhanced differentiation into human myeloid cells Ito R et al. J Immunol 2013
NOG-hIL-4 Tg Inhibition of GVHD Kametani Y et al. PloS One 2017
NOG-hIL-5 Tg Enhanced differentiation into human eosinophils Ito R et al. JCI Insight. 2018
NOG-hIL-6 Tg Induction of immunosuppressive macrophages Hanazawa A et al. Front Immunol. 2018
NOG-hIL-15 Tg Long-term maintenance of human NK cells Katano I et al. Scientific Reports 2018
NOG-hIL-1β/IL-23 Tg Induction of human Th17 cells  
NOG-hG-CSF KI Induction of differentiation into human neutrophils  
NOG-hM-CSF Tg Induction of differentiation into human macrophages  
C.B.17-scid-hIL-4 Tg HIV-infected model Okuma K et al. J infect dis 2008
BRG-hIL-4 Tg HIV-infected model Okuma K et al. J infect dis 2008
MHC/HLA genes
Strain Features Reference
NOG-HLA-A2 Tg Enhanced human cellular immune responses  
NOG-HLA-DRA/B 0405Tg Enhanced human humoral immune responses Suzuki M et al. Int Immunol 2012
NOG-Iab/b2m dKO Inhibition of GVHD Ashizawa T et al. Clin Cancer Res. 2017
Human bone marrow microenvironment
Strain Features Reference
NOG-Jagged1 Tg Osteoporosis model Negishi N et al. Exp Hematol 2014
NOG-Delta like 1 Tg Osteopetrosis-like model Ito R et al. Exp Hematol 2012
NOG-Wv/Wv, Wv/+ Enhanced engraftment of human hematopoietic system cells  
NOG Wsh/Wsh Depletion of murine mast cells  
NOG-SDF1α Tg Formulation of bone marrow niche  
NOG-SDF1β Tg Formulation of bone marrow niche  
NOG-N cadherin Tg Formulation of bone marrow niche  
NOG-Angiopoietin 1 Tg Formulation of bone marrow niche  
Human liver
Strain Features Reference
NOG-UPA Tg Human liver model Suemizu H et al. Biochem Biophys Res Commun 2008
NOG-TK Tg Human liver model Hasegawa M et al. Biochem Biophys Res Commun 2011
Hairless
Strain Features Reference
NOG-hairless Hairless NOG mouse  
BRG-nude Hairless BRG mouse  
Other
Strain Features Reference
NOG-pRORγt-γc Tg Recovery of murine lymphatic tissues Takahashi T et al. Front Immunol. 2018
NOG-EGFP Tg NOG mouse expressing systemic GFP Shima K et al. J Exp Clin Cancer Res 2012
NOG-mIFNγ Tg NOG mouse overexpressing murine IFNg  
NOD-scid-mIFNγ KO Murine IFNg knockout NOD-scid mouse Ito R et al. J Immunol 2012
BALB/c-RAG2, gc dKO (BRG) BALB/c background RAG2/IL-2Rgc knockout mouse Traggiai E et al. Science 2004
B6-RAG2, gc dKO (B6RG) B6 background RAG2/IL-2Rgc knockout mouse  
NOD-RAG2, gc dKO (NRG) NOD background RAG2/IL-2Rgc knockout mouse Katano I et al. Exp Anim 2014
NOG-bc KO NOG background cytokine common b chain knockout mouse  
Experimental Animals

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