Next generation immunodeficient mouse

NOG hIL-2 Tg Mouse

NOG hIL-2 Tg Mouse
Formal name	NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL2)3-2/Jic
Characteristic	Next generation humanized mouse expressing human IL-2 under the control of CMV promoter. After transplantation of human hematopoietic stem cells, human NK cells were dominantly differentiated.
Application	In vivo evaluation for ADCC (antibody-dependent cellular-cytotoxicity) activity via human NK cells Functional analysis of human NK cells
Reference	Katano I, et al. (2015) Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse. J Immunol 194(7):3513-3525
Differentiated human cell fraction after HSC transfusion

• NOG mouse
• TK-NOG mouse
• Next Generation NOG Mouse

• Common Marmoset
• Ras H2 mouse
• Polio mouse