| NOG hIL-3 GM-CSF Tg Mouse | |
|---|---|
| Formal name | NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(SRa-IL3, CSF2)7-2/Jic |
| Characteristic | Next generation humanized mouse expressing human IL-3 and GM-CSF under the control of the SRa promoter.
After transplantation of human hematopoietic stem cells, human myeloid lineage cells such as macrophages, dendritic cells, granulocytes, and mast cells, and CD4+ T cells are significantly differentiated. |
| Application | In vivo evaluation for human allergic reactions
In vivo evaluation for human myelotoxicity of anticancer drugs Engraftment of human myeloid leukemia Analysis of human innate immunity |
| Reference | Ito R, et al. (2013) Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice. J Immunol 191(6):2890-2899. |
| Differentiated human cell fraction after HSC transfusion |
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