Experimental Animals

Next generation immunodeficient mouse

NOG HLA-DR4 Tg mouse

Formal name NOD.Cg-Prkdcscid Il2rgtm1Sug Tg (IE-HLA-DRA*0101/HLA-DRB1*0405)/Jic
Characteristic Next generation humanized mouse expressing human HLA-DR4 genes under the control of the MHC-class II promoter.
Differentiation of functional human CD4+ T cells
Production of antigen-specific human IgG antibodies
Application Screening system for human antibodies
Analysis of human acquired immunity
Reference Suzuki M, et al. (2012) Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/gammacnull mouse. Int Immunol 24(4):243-252.
Differentiated human cell fraction after HSC transfusion HSC移入後に分化するヒト細胞分画
Experimental Animals

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