Next generation immunodeficient mouse

NOG HLA-DR4 Tg mouse

NOG HLA-DR4 Tg mouse
Formal name	NOD.Cg-Prkdcscid Il2rgtm1Sug Tg (IE-HLA-DRA*0101/HLA-DRB1*0405)/Jic
Characteristic	Next generation humanized mouse expressing human HLA-DR4 genes under the control of the MHC-class II promoter. Differentiation of functional human CD4+ T cells Production of antigen-specific human IgG antibodies
Application	Screening system for human antibodies Analysis of human acquired immunity
Reference	Suzuki M, et al. (2012) Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/gammacnull mouse. Int Immunol 24(4):243-252.
Differentiated human cell fraction after HSC transfusion

• NOG mouse
• TK-NOG mouse
• Next Generation NOG Mouse

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